Deep learning segmentation of hyperautofluorescent fleck lesions in Stargardt disease
نویسندگان
چکیده
منابع مشابه
Fundus autofluorescence patterns in stargardt disease over time.
OBJECTIVE To study the longitudinal changes in autofluorescence in Stargardt disease to reveal aspects of disease progression not previously evident. Changes in autofluorescence reflect changing fluorophore compositions of lipofuscin and melanin in retinal pigment epithelial cells, which has been hypothesized to contribute to Stargardt disease pathogenesis. METHODS We examined the temporospat...
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Background: Multiple Sclerosis (MS) is a degenerative disease of central nervous system. MS patients have some dead tissues in their brains called MS lesions. MRI is an imaging technique sensitive to soft tissues such as brain that shows MS lesions as hyper-intense or hypo-intense signals. Since manual segmentation of these lesions is a laborious and time consuming task, automatic segmentation ...
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We present a deep convolutional neural network approach for producing semantic segmentations. First, we generalize the architecture of the successful Alexnet network [7] to directly predict coarse segmentations. Second, we produce full resolution segmentations by re-ranking a diverse set of plausible segmentation proposals generated from a recent state of the art approach [9].
متن کاملPeripapillary atrophy in Stargardt disease.
OBJECTIVE To demonstrate that Stargardt disease (STGD) can present with peripapillary atrophy. METHODS Retrospective case series. The medical records of 150 consecutive patients (300 eyes) were reviewed retrospectively from a STGD database from January 1999 to May 2007 at Columbia University's Harkness Eye Institute. STGD patients demonstrating peripapillary atrophy were identified. RESULTS...
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PURPOSE To report genetic and phenotypic discordance across two generations of a family with autosomal recessive Stargardt disease (STGD1) and to compare pathogenicities of the G1961E and A1038V alleles of the ATP-binding cassette transporter, subfamily A, member 4 (ABCA4) gene. METHODS Five members of a family with STGD1 (patients 1-4, affected; patient 5, carrier) were included. Clinical as...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2020
ISSN: 2045-2322
DOI: 10.1038/s41598-020-73339-y